殺戮間2代對於怪物相對之前原版的設定來說出現了很多的變化，特別一些新怪物的設定更是相比之前有著巨大的變化，這裡是從網上包括各個地方蒐集到的非常有限的信息，也包括一些還處於設定階段，還尚未為大家所知的新怪物。

Han Volter 漢斯.沃爾特

「He is a 100-year-old Nazi evil doctor character that is keeping himself alive with Horzine technology.」

—John Gibson, president of Tripwire Interactive

他是一個已經100歲的前納粹科學家，其借助地平線公司的生物技術來維持自己的生命。

——約翰·吉布森 TWI執行總裁

Originally known as "Unknown Boss", Hans Volter is one of the boss characters that appears in Killing Floor 2 and currently is the only boss the players may face. He bears a slight visual resemblance to the Patriarch, topless and wearing trousers, but appears to be altered only with various Horzine-made hardware rather than being enhanced with hardware and biologically like the Patriarch. When Hans' health drops to a certain level, he will charge one of the players, catch them and drain their health, replenishing his own. After each health-drain, Hans will employ a new attack. His other attacks include weaker melee attacks, ranged - toxic grenades, HE grenades, he also appears to dual wield StG 44/MkB 42.

作為原來消息中的「未知BOSS」， Hans Volter是將出現在殺戮空間2中幾名BOSS中的一個，而且他也是目前為止玩家所唯一要面對的BOSS。他與原版的Patriarch有幾分相似，但 Hans Volter與前者的不同在於其裝備有不一樣的地平線科技硬件而非像Patriarch一樣幾乎是單純的生物學上的增強。當Hans的生命值生命值降低的 一定數量的時候他就會從一名玩家身上吸血，抓住玩家並抽取玩家的生命值為他所用，每當他的生命值降低，他都會使用一種新的攻擊招式，他會使用包括較弱的近 戰攻擊、遠程毒氣手雷和高爆手雷，他也會使用隨身攜帶的雙持MKB42來向玩家射擊。

可能Hans Volter的二戰武器裝備和納粹背景很大一部分是在向紅色管絃樂系列致敬。

Scrake Variant 變種Scrake

A Scrake variant may appear in the game. This has been stated by developer Jared Creasy "Also known on the interwebs as Yoshiro"

變種Scrake仍然有機會出現在遊戲當中，這個信息已經被T社開發者Jared Creasy ，也就是大家熟知Yoshiro說明過。

這是在遊戲中已經存在的單持電鋸Scrake，可以看做是原版SC.

後者的雙持電鋸SC，出現在Weapon&Perk 1 Demo裡。

「The reason we didn't show him sooner (whichwe have commented on btw) is because he was undergoing a redesign at the timethe videos came out. We didn't like himso we re-did him. The new "old" Scrake may see the light of day as anew zed or we may use some of the mechanics we were working on for it as partof another one. We will see.」

我們並沒有公佈他的原因在於這是一個經歷重新設計的過程，我們並不喜歡雙持電鋸的設定所以我們重制了他，這個更「新」的原版Scrake在公示之後或許會比另一種更令人接受，拭目以待吧。

——Yoshiro

Twin-Bladed Gorefast 雙刃小紅

A Gorefast variant was mentioned by the Trader. Much like the Slasher is a more fierce variant of the Clot, this Twin-bladed Gorefast is most likely just a variant version with slight differences. Something similar appeared in Killing Floor, where the Gorefast had a unused variant named the GorefastSP, which was simply a faster Gorefast.

被Trader提及過的Gorefast變種，就如同Slasher是Clot變種一樣，這種Gorefast變異體會在外觀上與原版不同，就 如同在原版殺戮間曾有一個棄用的 Gorefast變種叫做 GorefastSP，其不同的僅僅在於他比原版Gorefast更快一些。

Patriarch 復仇者、博士

It has been stated that the main antagonist, the Patriarch, retains his role as the final boss enemy. Though playable demos to the press have the Patriarch in the game, TWI has prohibited any photography or recordings allowed, thus the public is unaware of his new appearance.

作為玩家的死對頭，Patriarch將以最終BOSS回歸，不過由於T社現在禁止關於Patriarch的視頻資料對外發行，所以Patriarch在2代中的狀態仍然不為人知。

[Kevin Clamely]

"Under my scientific leadership, Horzine has achieved unparalleled success, and is trusted the world over."

"We are driving the renaissance of science."

"We are-"

[Mid transformed Kevin]

"-progress of bio-engineering."

"We are the vision of technology."

"We are-(static)-genetics..."

"We are your evolution..."

"I AM YOUR FUTURE..."

"I AM THE POWER-"(distortion)

[Patriarch]

"I AM DEATH!"

這是Patriarch，也就是地平線CEO Kevin Clamely在殺戮間2宣傳片中的講述。

Matriarch 女族長

A Matriarch was mentioned by the Trader. She explains that the Matriarch will pilot a mechsuit which she can and will abandon and attack the player herself as her "true form". There is no word of her by the developers and no visual evidence as of now if she is either a standard KFGametype boss or a objective mode one.

A Matriarch was planned at one point for a community update for KFMod 2.6+ but was cancelled due to Tripwire Interactive already acquiring the rights to Killing Floor. The KFMod Matriarch was to have cloaking abilities and would be able to drain health from the players.

被Trader提到過的「 Matriarch 」，她解釋說 Matriarch 會操作一套機械動力服戰鬥，並且會在某些情況下放棄戰鬥服以「真身」來對付玩家。關於Matriarch，開發者並沒有對其有過多的解釋，而且也沒有任何 可見的資料能夠證明她或許任務模式BOSS中的一員。

Matriarch早在KFmod 2.6+的時候就被考慮添加在遊戲中，但由於之後T社為開發殺戮間獨立版而放棄了這一個計劃，在KFmod中Matriarch被設定為能夠隱形和從玩家身上吸取生命值為自己所用。